Mirny Lab

Tag: Leonid Mirny

  • Grand Public Lecture of the Institut d’Études Scientifiques, Cargèse

    Grand Public Lecture of the Institut d’Études Scientifiques, Cargèse

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    Professors Leonid Mirny and Emmanuelle Fabre will be presenting the Grand Public Lecture of the Institut d’Études Scientifiques on June 3 in Cargèse, France. THE GENOME: NOW IN 3D! Our genomes are the carrier of the genetic information necessary for the life of our cells and the entire organism. This information is faithfully transmitted from…

  • Leonid Mirny presented with the Tel Aviv University International Prize in Biophysics

    Leonid Mirny presented with the Tel Aviv University International Prize in Biophysics

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    On May 12th in Tel Aviv, Leonid Mirny was honored with the 2024 Tel Aviv University International Prize in Biophysics. The award ceremony was part of a symposium that also celebrated fellow laureates: Professor Cees Dekker of Delft University of Technology, also a 2024 recipient, and Professor Ariel Amir of the Weizmann Institute of Science,…

  • Alumni Visits

    Alumni Visits

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    We were so happy to have lab alumni visiting this Spring! Welcoming Simon Grosse-Holz, currently at the Center for Systems Biology Dresden and Carino Gurjao, Assistant Professor of Medicine at Université de Montréal/ Institute for Research in Immunology and Cancer of the Université de Montréal for a visit made us realize how much we miss…

  • Welcoming Prof. Valentina Boeva to Campus

    Welcoming Prof. Valentina Boeva to Campus

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    We had the pleasure of hosting Professor Valentina Boeva from ETH Zurich today for a special joint group meeting with the Hansen lab. Dr. Boeva, who leads the Computational Cancer Genomics Group, shared her recent work on “UniversalEPI: harnessing attention mechanisms to decode chromatin interactions in rare and unexplored cell types.” The day provided a…

  • Genome-wide absolute quantification of chromatin looping

    Genome-wide absolute quantification of chromatin looping

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    James M. Jusuf, Simon Grosse-Holz, Michele Gabriele, Pia Mach, Ilya M. Flyamer, Christoph Zechner, Luca Giorgetti, Leonid A. Mirny, Anders S. HansenGenome-wide absolute quantification of chromatin loopingbioRxiv 2025.01.13.632736; doi: https://doi.org/10.1101/2025.01.13.632736 Abstract 3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these…

  • Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding

    Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding

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    Ànnia Carré-Simon, Renaud Batrin, Sarah Isler, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Maria Barbi, Leonid Mirny, Damien D’Amours, Emmanuelle FabreSmc5/6 association with microtubules controls dynamic pericentromeric chromatin foldingbioRxiv 2024.11.13.623393; doi: https://doi.org/10.1101/2024.11.13.623393 Abstract Centromeres and pericentromeres are specialized chromatin regions whose organization is critical for proper chromosome segregation through dynamic microtubule attachment. Smc5/6, highly enriched…

  • Cargèse‘Physics Meets Genomes’ Summer School in Cargèse

    Cargèse‘Physics Meets Genomes’ Summer School in Cargèse

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    The “Physics Meets Genomes” Conference and Summer School will train a new generation of researchers at this important intersection of disciplines to advance the study of nuclear processes. The Summer school will also create opportunities for exchange, collaboration, and development of new ideas among a focused group of researchers working at the intersection of biology…

  • Muse-IC project

    Muse-IC project

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    The Muse-IC project offers composers the opportunity to create a musical work directly inspired by a recent scientific discovery in the fields of astrophysics, biology, and biophysics. This documentary relates the interactions between scientists and composers between 2017 and 2019, including interviews of researchers, composers as well as extract of their compositions. The pieces composed…

  • Sackler Prize in Biophysics renamed after three laureates call for a name change

    Sackler Prize in Biophysics renamed after three laureates call for a name change

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    Following a ScienceInsider feature in the June 2024 issue for Science in which all three laureates called for renaming the prize, Tel Aviv University has renamed the prestigious Raymond and Beverly Sackler International Prize in Biophysics to the Tel Aviv University International prize in Physics. “It is never too late to counteract the name washing…

  • The chromosome folding problem and how cells solve it

    The chromosome folding problem and how cells solve it

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    Dekker J, Mirny LA. The chromosome folding problem and how cells solve it. Cell. 2024 Nov 14;187(23):6424-6450. doi: 10.1016/j.cell.2024.10.026. PMID: 39547207; PMCID: PMC11569382. doi: https://doi.org/10.1016/j.cell.2024.10.026 Abstract Every cell must solve the problem of how to fold its genome. We describe how the folded state of chromosomes is the result of the combined activity of multiple…

  • Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille

    Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille

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    Laureates of the Raymond and Beverly Sackler International Prize in Biophysics for the Year 2024 Prof. Cornelis (Cees) Dekker, Delft University of Technology, The Netherlands For his seminal contributions to single-molecule biophysics, including the application of nanotechnology to biological systems, developing single-molecule techniques leading to breakthroughs in DNA and protein sequencing with nanopores, novel insights…

  • Dynamics of microcompartment formation at the mitosis-to-G1 transition

    Dynamics of microcompartment formation at the mitosis-to-G1 transition

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    Dynamics of microcompartment formation at the mitosis-to-G1 transition Viraat Y. Goel, Nicholas G. Aboreden, James M. Jusuf, Haoyue Zhang, Luisa P. Mori, Leonid A. Mirny, Gerd A. Blobel, Edward J. Banigan, Anders S. Hansen bioRxiv 2024.09.16.611917; doi: https://doi.org/10.1101/2024.09.16.611917  This article is a preprint and has not been certified by peer review Abstract As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D…

  • HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

    HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

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    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.27.609896; doi: https://doi.org/10.1101/2024.08.27.609896  This article is a preprint and has not been certified by peer review Abstract The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these levels of organisation is unknown. Here, we…

  • HIRA defines early replication initiation zones independently of their genome compartment

    HIRA defines early replication initiation zones independently of their genome compartment

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    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.29.610220; doi: https://doi.org/10.1101/2024.08.29.610220  This article is a preprint and has not been certified by peer review  Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the…

  • Does chromatin organization shape immune responses? 

    Does chromatin organization shape immune responses? 

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    Our recent study with Nick Adams of the Reizis Lab and Leonid Mirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells 

  • Science, Sun, and Seaworms. Falmouth 2024

    Science, Sun, and Seaworms. Falmouth 2024

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    The lab escaped to Falmouth for 4 days of science and summer. We had two days packed with talks by lab members and guests (Johan Gibcus and Anders Hansen) where we caught up on each other’s work and discussed the exciting directions our research is heading in the next year. We were lucky to visited…

  • 2024 Summer School Lectures & Genome Architecture and Function Workshop | Boston, MA

    2024 Summer School Lectures & Genome Architecture and Function Workshop | Boston, MA

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    Ed Banigan and Aleksandra Galisyna help co-organize the 2024 International Summer School & Genome Architecture and Function Workshop this July 8th to 12th at Northeastern University. Ed and Sasha organized speakers and the summer school, increasing the diversity and participation by your researchers.

  • Spandrels of the Cell Nucleus

    Spandrels of the Cell Nucleus

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    Irina Solovei, Leonid Mirny,Spandrels of the cell nucleus,Current Opinion in Cell Biology,Volume 90,2024,102421,ISSN 0955-0674,https://doi.org/10.1016/j.ceb.2024.102421.(https://www.sciencedirect.com/science/article/pii/S0955067424001005) “S.J. Gould and R. Lewontin in their famous “Spandrels paper” (1979) argued that many anatomical elements arise in evolution not due to their “current utility” but rather due to other “reasons for origin”, such as other developmental processes, physical constraints and…