Mirny Lab

Tag: Leonid Mirny

  • Genome-wide absolute quantification of chromatin looping

    Genome-wide absolute quantification of chromatin looping

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    James M. Jusuf, Simon Grosse-Holz, Michele Gabriele, Pia Mach, Ilya M. Flyamer, Christoph Zechner, Luca Giorgetti, Leonid A. Mirny, Anders S. HansenGenome-wide absolute quantification of chromatin loopingbioRxiv 2025.01.13.632736; doi: https://doi.org/10.1101/2025.01.13.632736 Abstract 3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these…

  • Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding

    Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding

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    Ànnia Carré-Simon, Renaud Batrin, Sarah Isler, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Maria Barbi, Leonid Mirny, Damien D’Amours, Emmanuelle FabreSmc5/6 association with microtubules controls dynamic pericentromeric chromatin foldingbioRxiv 2024.11.13.623393; doi: https://doi.org/10.1101/2024.11.13.623393 Abstract Centromeres and pericentromeres are specialized chromatin regions whose organization is critical for proper chromosome segregation through dynamic microtubule attachment. Smc5/6, highly enriched…

  • Cargèse‘Physics Meets Genomes’ Summer School in Cargèse

    Cargèse‘Physics Meets Genomes’ Summer School in Cargèse

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    The “Physics Meets Genomes” Conference and Summer School will train a new generation of researchers at this important intersection of disciplines to advance the study of nuclear processes. The Summer school will also create opportunities for exchange, collaboration, and development of new ideas among a focused group of researchers working at the intersection of biology…

  • Muse-IC project

    Muse-IC project

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    The Muse-IC project offers composers the opportunity to create a musical work directly inspired by a recent scientific discovery in the fields of astrophysics, biology, and biophysics. This documentary relates the interactions between scientists and composers between 2017 and 2019, including interviews of researchers, composers as well as extract of their compositions. The pieces composed…

  • Sackler Prize in Biophysics renamed after three laureates call for a name change

    Sackler Prize in Biophysics renamed after three laureates call for a name change

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    Following a ScienceInsider feature in the June 2024 issue for Science in which all three laureates called for renaming the prize, Tel Aviv University has renamed the prestigious Raymond and Beverly Sackler International Prize in Biophysics to the Tel Aviv University International prize in Physics. “It is never too late to counteract the name washing…

  • The chromosome folding problem and how cells solve it

    The chromosome folding problem and how cells solve it

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    Dekker J, Mirny LA. The chromosome folding problem and how cells solve it. Cell. 2024 Nov 14;187(23):6424-6450. doi: 10.1016/j.cell.2024.10.026. PMID: 39547207; PMCID: PMC11569382. doi: https://doi.org/10.1016/j.cell.2024.10.026 Abstract Every cell must solve the problem of how to fold its genome. We describe how the folded state of chromosomes is the result of the combined activity of multiple…

  • Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille

    Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille

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    Laureates of the Raymond and Beverly Sackler International Prize in Biophysics for the Year 2024 Prof. Cornelis (Cees) Dekker, Delft University of Technology, The Netherlands For his seminal contributions to single-molecule biophysics, including the application of nanotechnology to biological systems, developing single-molecule techniques leading to breakthroughs in DNA and protein sequencing with nanopores, novel insights…

  • Dynamics of microcompartment formation at the mitosis-to-G1 transition

    Dynamics of microcompartment formation at the mitosis-to-G1 transition

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    Dynamics of microcompartment formation at the mitosis-to-G1 transition Viraat Y. Goel, Nicholas G. Aboreden, James M. Jusuf, Haoyue Zhang, Luisa P. Mori, Leonid A. Mirny, Gerd A. Blobel, Edward J. Banigan, Anders S. Hansen bioRxiv 2024.09.16.611917; doi: https://doi.org/10.1101/2024.09.16.611917  This article is a preprint and has not been certified by peer review Abstract As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D…

  • HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

    HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

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    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.27.609896; doi: https://doi.org/10.1101/2024.08.27.609896  This article is a preprint and has not been certified by peer review Abstract The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these levels of organisation is unknown. Here, we…

  • HIRA defines early replication initiation zones independently of their genome compartment

    HIRA defines early replication initiation zones independently of their genome compartment

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    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.29.610220; doi: https://doi.org/10.1101/2024.08.29.610220  This article is a preprint and has not been certified by peer review  Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the…