Tag: Leonid Mirny
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Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille
Laureates of the Raymond and Beverly Sackler International Prize in Biophysics for the Year 2024 Prof. Cornelis (Cees) Dekker, Delft University of Technology, The Netherlands For his seminal contributions to single-molecule biophysics, including the application of nanotechnology to biological systems, developing single-molecule techniques leading to breakthroughs in DNA and protein sequencing with nanopores, novel insights…
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Dynamics of microcompartment formation at the mitosis-to-G1 transition
in PublicationsDynamics of microcompartment formation at the mitosis-to-G1 transition Viraat Y. Goel, Nicholas G. Aboreden, James M. Jusuf, Haoyue Zhang, Luisa P. Mori, Leonid A. Mirny, Gerd A. Blobel, Edward J. Banigan, Anders S. Hansen bioRxiv 2024.09.16.611917; doi: https://doi.org/10.1101/2024.09.16.611917 This article is a preprint and has not been certified by peer review Abstract As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D…
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HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation
T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.27.609896; doi: https://doi.org/10.1101/2024.08.27.609896 This article is a preprint and has not been certified by peer review Abstract The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these levels of organisation is unknown. Here, we…
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HIRA defines early replication initiation zones independently of their genome compartment
T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.29.610220; doi: https://doi.org/10.1101/2024.08.29.610220 This article is a preprint and has not been certified by peer review Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the…
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Does chromatin organization shape immune responses?
in PublicationsOur recent study with Nick Adams of the Reizis Lab and Leonid Mirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells
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Science, Sun, and Seaworms. Falmouth 2024
The lab escaped to Falmouth for 4 days of science and summer. We had two days packed with talks by lab members and guests (Johan Gibcus and Anders Hansen) where we caught up on each other’s work and discussed the exciting directions our research is heading in the next year. We were lucky to visited…
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2024 Summer School Lectures & Genome Architecture and Function Workshop | Boston, MA
Ed Banigan and Aleksandra Galisyna help co-organize the 2024 International Summer School & Genome Architecture and Function Workshop this July 8th to 12th at Northeastern University. Ed and Sasha organized speakers and the summer school, increasing the diversity and participation by your researchers.
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Spandrels of the Cell Nucleus
Irina Solovei, Leonid Mirny,Spandrels of the cell nucleus,Current Opinion in Cell Biology,Volume 90,2024,102421,ISSN 0955-0674,https://doi.org/10.1016/j.ceb.2024.102421.(https://www.sciencedirect.com/science/article/pii/S0955067424001005) “S.J. Gould and R. Lewontin in their famous “Spandrels paper” (1979) argued that many anatomical elements arise in evolution not due to their “current utility” but rather due to other “reasons for origin”, such as other developmental processes, physical constraints and…