In the Loop
Mirny Lab updates
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Sackler Prize in Biophysics renamed after three laureates call for a name change
Following a ScienceInsider feature in the June 2024 issue for Science in which all three laureates called for renaming the prize, Tel Aviv University has renamed the prestigious Raymond and Beverly Sackler International Prize in Biophysics to the Tel Aviv University International prize in Physics. “It is never too late to counteract the name washing…
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The chromosome folding problem and how cells solve it
Dekker J, Mirny LA. The chromosome folding problem and how cells solve it. Cell. 2024 Nov 14;187(23):6424-6450. doi: 10.1016/j.cell.2024.10.026. PMID: 39547207; PMCID: PMC11569382. doi: https://doi.org/10.1016/j.cell.2024.10.026 Abstract Every cell must solve the problem of how to fold its genome. We describe how the folded state of chromosomes is the result of the combined activity of multiple…
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The World Called
Soprano and Mirny Lab postdoc, Aleksandra Galitsyna, performed a beautiful program of Anton Bruckner, Adolphus Hailstorck and Francis Poulec with the MIT Concert Choir in Kresge Auditorium. The choir was particularly proud to host Adolphus Hailstorck for the East Coast premier of his work “The World Called”. Congratulations!
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Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille
Laureates of the Raymond and Beverly Sackler International Prize in Biophysics for the Year 2024 Prof. Cornelis (Cees) Dekker, Delft University of Technology, The Netherlands For his seminal contributions to single-molecule biophysics, including the application of nanotechnology to biological systems, developing single-molecule techniques leading to breakthroughs in DNA and protein sequencing with nanopores, novel insights…
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Rt.1 shopping tour for Irina!
This weekend, Aleksandra, Irina, and I went on a Sunday shopping adventure to help Irina find the finishing touches for her apartment. Our first stop was Savers, where we were soon lost in the sheer variety of treasures. Aleksandra scored a practical shelving unit. Irina was able to fill in the housewares that she was…
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Dynamics of microcompartment formation at the mitosis-to-G1 transition
Dynamics of microcompartment formation at the mitosis-to-G1 transition Viraat Y. Goel, Nicholas G. Aboreden, James M. Jusuf, Haoyue Zhang, Luisa P. Mori, Leonid A. Mirny, Gerd A. Blobel, Edward J. Banigan, Anders S. Hansen bioRxiv 2024.09.16.611917; doi: https://doi.org/10.1101/2024.09.16.611917 This article is a preprint and has not been certified by peer review Abstract As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D…
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HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation
T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.27.609896; doi: https://doi.org/10.1101/2024.08.27.609896 This article is a preprint and has not been certified by peer review Abstract The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these levels of organisation is unknown. Here, we…
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HIRA defines early replication initiation zones independently of their genome compartment
T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.29.610220; doi: https://doi.org/10.1101/2024.08.29.610220 This article is a preprint and has not been certified by peer review Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the…
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Does chromatin organization shape immune responses?
Our recent study with Nick Adams of the Reizis Lab and Leonid Mirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells
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Science, Sun, and Seaworms. Falmouth 2024
The lab escaped to Falmouth for 4 days of science and summer. We had two days packed with talks by lab members and guests (Johan Gibcus and Anders Hansen) where we caught up on each other’s work and discussed the exciting directions our research is heading in the next year. We were lucky to visited…