In the Loop
Mirny Lab updates
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The chromosome folding problem and how cells solve it
Dekker J, Mirny LA. The chromosome folding problem and how cells solve it. Cell. 2024 Nov 14;187(23):6424-6450. doi: 10.1016/j.cell.2024.10.026. PMID: 39547207; PMCID: PMC11569382. doi: https://doi.org/10.1016/j.cell.2024.10.026 Abstract Every cell must solve the problem of how to fold its genome. We describe how the folded state of chromosomes is the result of the combined activity of multiple…
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Grand Public Lecture of the Institut d’Études Scientifiques, Cargèse
Professors Leonid Mirny and Emmanuelle Fabre will be presenting the Grand Public Lecture of the Institut d’Études Scientifiques on June 3 in Cargèse, France. THE GENOME: NOW IN 3D! Our genomes are the carrier of the genetic information necessary for the life of our cells and the entire organism. This information is faithfully transmitted from…
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Leonid Mirny presented with the Tel Aviv University International Prize in Biophysics
On May 12th in Tel Aviv, Leonid Mirny was honored with the 2024 Tel Aviv University International Prize in Biophysics. The award ceremony was part of a symposium that also celebrated fellow laureates: Professor Cees Dekker of Delft University of Technology, also a 2024 recipient, and Professor Ariel Amir of the Weizmann Institute of Science,…
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Alumni Visits
We were so happy to have lab alumni visiting this Spring! Welcoming Simon Grosse-Holz, currently at the Center for Systems Biology Dresden and Carino Gurjao, Assistant Professor of Medicine at Université de Montréal/ Institute for Research in Immunology and Cancer of the Université de Montréal for a visit made us realize how much we miss…
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Welcoming Prof. Valentina Boeva to Campus
We had the pleasure of hosting Professor Valentina Boeva from ETH Zurich today for a special joint group meeting with the Hansen lab. Dr. Boeva, who leads the Computational Cancer Genomics Group, shared her recent work on “UniversalEPI: harnessing attention mechanisms to decode chromatin interactions in rare and unexplored cell types.” The day provided a…
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Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Kumiko Samejima et al. , Rules of engagement for condensins and cohesins guide mitotic chromosome formation.Science388,eadq1709(2025).DOI:10.1126/science.adq1709 Editor’s summaryStructural maintenance of chromosomes (SMC) protein complexes, which include cohesin and condensin, play crucial roles in chromatin organization during the interphase and mitosis steps of the cell cycle. Samejima et al. investigated how these complexes interact and guide mitotic…
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Genome-wide absolute quantification of chromatin looping
James M. Jusuf, Simon Grosse-Holz, Michele Gabriele, Pia Mach, Ilya M. Flyamer, Christoph Zechner, Luca Giorgetti, Leonid A. Mirny, Anders S. HansenGenome-wide absolute quantification of chromatin loopingbioRxiv 2025.01.13.632736; doi: https://doi.org/10.1101/2025.01.13.632736 Abstract 3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these…
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Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding
Ànnia Carré-Simon, Renaud Batrin, Sarah Isler, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Maria Barbi, Leonid Mirny, Damien D’Amours, Emmanuelle FabreSmc5/6 association with microtubules controls dynamic pericentromeric chromatin foldingbioRxiv 2024.11.13.623393; doi: https://doi.org/10.1101/2024.11.13.623393 Abstract Centromeres and pericentromeres are specialized chromatin regions whose organization is critical for proper chromosome segregation through dynamic microtubule attachment. Smc5/6, highly enriched…
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Welcome Tingran Wang!
Tingran Wang, doctoral student in the MIT physics Department will be joining our lab for a 3-month rotation. During his rotation, Tingran will be collaborating with Henrik Pinholt and Timothy Foldes. They will be investigating how stretched chromatins in vivo can tell us more about their polymer properties, and eventually directly see evidence of loop…
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Cargèse‘Physics Meets Genomes’ Summer School in Cargèse
The “Physics Meets Genomes” Conference and Summer School will train a new generation of researchers at this important intersection of disciplines to advance the study of nuclear processes. The Summer school will also create opportunities for exchange, collaboration, and development of new ideas among a focused group of researchers working at the intersection of biology…
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Muse-IC project
The Muse-IC project offers composers the opportunity to create a musical work directly inspired by a recent scientific discovery in the fields of astrophysics, biology, and biophysics. This documentary relates the interactions between scientists and composers between 2017 and 2019, including interviews of researchers, composers as well as extract of their compositions. The pieces composed…