Architecture and Physics of the Genome
What are the physical principles and processes connecting 3D folding to genome function?
The challenge of understanding biological systems from first physical principles is what motivates our research. Biological systems are characterized by remarkable structural complexity at all levels of organization. However, we believe that simple physical models are valuable for describing these systems.
- Gene Regulation
- Epigenic Memory
- Cell Division
- Chromosome Abnormalities in Cancer
- DNA Repair
- Immune Response
Our laboratory develops multidisciplinary approaches involving:
- Polymer physics theory and simulation
- Statistical interpretation of genome-wide data
- Population genetics and evolutionary theory
The future of genome architecture is being shaped within our lab
The Mirny Lab fosters a thriving community of talented scientists, providing mentorship and support to researchers at all stages, from secondary school PRIMES students to postdoctoral researchers.
“Everything that living things do can be understood in terms of the jigglings and wigglings of atoms.”
