Mirny Lab

Category: Publications

  • Dynamics of microcompartment formation at the mitosis-to-G1 transition

    Dynamics of microcompartment formation at the mitosis-to-G1 transition

    in

    Dynamics of microcompartment formation at the mitosis-to-G1 transition Viraat Y. Goel, Nicholas G. Aboreden, James M. Jusuf, Haoyue Zhang, Luisa P. Mori, Leonid A. Mirny, Gerd A. Blobel, Edward J. Banigan, Anders S. Hansen bioRxiv 2024.09.16.611917; doi: https://doi.org/10.1101/2024.09.16.611917  This article is a preprint and has not been certified by peer review Abstract As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D…

  • HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

    HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

    in ,

    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.27.609896; doi: https://doi.org/10.1101/2024.08.27.609896  This article is a preprint and has not been certified by peer review Abstract The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these levels of organisation is unknown. Here, we…

  • HIRA defines early replication initiation zones independently of their genome compartment

    HIRA defines early replication initiation zones independently of their genome compartment

    in ,

    T. Karagyozova, A. Gatto, A. Forest, J.-P. Quivy, M. Marti-Renom, L. Mirny, G. Almouzni bioRxiv 2024.08.29.610220; doi: https://doi.org/10.1101/2024.08.29.610220  This article is a preprint and has not been certified by peer review  Abstract Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relationships by focusing on the…

  • Does chromatin organization shape immune responses? 

    Does chromatin organization shape immune responses? 

    in

    Our recent study with Nick Adams of the Reizis Lab and Leonid Mirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells 

  • Spandrels of the Cell Nucleus

    Spandrels of the Cell Nucleus

    in ,

    Irina Solovei, Leonid Mirny,Spandrels of the cell nucleus,Current Opinion in Cell Biology,Volume 90,2024,102421,ISSN 0955-0674,https://doi.org/10.1016/j.ceb.2024.102421.(https://www.sciencedirect.com/science/article/pii/S0955067424001005) “S.J. Gould and R. Lewontin in their famous “Spandrels paper” (1979) argued that many anatomical elements arise in evolution not due to their “current utility” but rather due to other “reasons for origin”, such as other developmental processes, physical constraints and…