Category: News
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Genome-wide absolute quantification of chromatin looping
James M. Jusuf, Simon Grosse-Holz, Michele Gabriele, Pia Mach, Ilya M. Flyamer, Christoph Zechner, Luca Giorgetti, Leonid A. Mirny, Anders S. HansenGenome-wide absolute quantification of chromatin loopingbioRxiv 2025.01.13.632736; doi: https://doi.org/10.1101/2025.01.13.632736 Abstract 3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these…
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Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding
Ànnia Carré-Simon, Renaud Batrin, Sarah Isler, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Maria Barbi, Leonid Mirny, Damien D’Amours, Emmanuelle FabreSmc5/6 association with microtubules controls dynamic pericentromeric chromatin foldingbioRxiv 2024.11.13.623393; doi: https://doi.org/10.1101/2024.11.13.623393 Abstract Centromeres and pericentromeres are specialized chromatin regions whose organization is critical for proper chromosome segregation through dynamic microtubule attachment. Smc5/6, highly enriched…
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Welcome Tingran Wang!
Tingran Wang, doctoral student in the MIT physics Department will be joining our lab for a 3-month rotation. During his rotation, Tingran will be collaborating with Henrik Pinholt and Timothy Foldes. They will be investigating how stretched chromatins in vivo can tell us more about their polymer properties, and eventually directly see evidence of loop…
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Cargèse‘Physics Meets Genomes’ Summer School in Cargèse
The “Physics Meets Genomes” Conference and Summer School will train a new generation of researchers at this important intersection of disciplines to advance the study of nuclear processes. The Summer school will also create opportunities for exchange, collaboration, and development of new ideas among a focused group of researchers working at the intersection of biology…
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Muse-IC project
The Muse-IC project offers composers the opportunity to create a musical work directly inspired by a recent scientific discovery in the fields of astrophysics, biology, and biophysics. This documentary relates the interactions between scientists and composers between 2017 and 2019, including interviews of researchers, composers as well as extract of their compositions. The pieces composed…
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MIT PRIMES
MIT PRIMES is a free, year-long program, in which high school students work on individual and group research projects in mathematics, computer science or bioinformatics and computational biology and participate in reading groups under the guidance of academic mentors, usually graduate students or postdoctoral scholars. The Mirny lab is very proud of our Prime graduates…
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Sackler Prize in Biophysics renamed after three laureates call for a name change
Following a ScienceInsider feature in the June 2024 issue for Science in which all three laureates called for renaming the prize, Tel Aviv University has renamed the prestigious Raymond and Beverly Sackler International Prize in Biophysics to the Tel Aviv University International prize in Physics. “It is never too late to counteract the name washing…
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The chromosome folding problem and how cells solve it
Dekker J, Mirny LA. The chromosome folding problem and how cells solve it. Cell. 2024 Nov 14;187(23):6424-6450. doi: 10.1016/j.cell.2024.10.026. PMID: 39547207; PMCID: PMC11569382. doi: https://doi.org/10.1016/j.cell.2024.10.026 Abstract Every cell must solve the problem of how to fold its genome. We describe how the folded state of chromosomes is the result of the combined activity of multiple…
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The World Called
Soprano and Mirny Lab postdoc, Aleksandra Galitsyna, performed a beautiful program of Anton Bruckner, Adolphus Hailstorck and Francis Poulec with the MIT Concert Choir in Kresge Auditorium. The choir was particularly proud to host Adolphus Hailstorck for the East Coast premier of his work “The World Called”. Congratulations!
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Leonid Mirny shares the Sackler Prize with Cees Dekker and Petra Schwille
Laureates of the Raymond and Beverly Sackler International Prize in Biophysics for the Year 2024 Prof. Cornelis (Cees) Dekker, Delft University of Technology, The Netherlands For his seminal contributions to single-molecule biophysics, including the application of nanotechnology to biological systems, developing single-molecule techniques leading to breakthroughs in DNA and protein sequencing with nanopores, novel insights…