Heterochromatin drives organization of conventional and inverted nuclei

Martin Falk*, Yana Feodorova*, Natasha Naumova*, Maxim Imakaev, Bryan R. Lajoie, Heinrich Leonhardt, Boris Joffe, Job Dekker, Geoffrey Fudenberg, Irina Solovei, Leonid Mirny

Nature 570, 395–399 doi:10.1038/s41586-019-1275-3

bioRxiv (Jan, 2018) doi:10.1101/244038

HiGlass Displays

A dramatic and global change in chromatin architecture observed in microscopy (nuclear inversion) does little to affect the compartmentalization (checkerboard pattern) of Hi-C data.