Principal Investigator

Leonid Mirny

Professor of Medical Engineering and Science, and Physics

Current Affiliations:
  • Institute for Medical Engineering and Science, and Department of Physics, Massachusetts Institute of Technology
  • Associate Member of the Broad Institute
  • Associate Member of the Dana-Farber Cancer Institute
Past Affiliations:



Postdoctoral Fellows

Maxim Imakaev

MIT Physics, Ph.D.

My main research centers around 3D genome organization: polymer models of the genomes of different organisms, and Hi-C data analysis. I am also studing the effects of topological constraints on polymer melts, a follow-up to my previous work on the fractal globule model of interphase chromatin.



Geoff Fudenberg

Harvard Biophysics, Ph.D.

3D Genome Organization: Physical models, statistical methods, and comparative genomics.



Dina Tsukrov

Ph.D. in Biomedical Science, Department of Microbiology and Immunology, at the Albert Einstein College of Medicine (2015)

M.Sc. in Biomedical Science at the Albert Einstein College of Medicine (2012)

Sc.B in Biomedical Engineering at Brown University (2008)

Exploring the balance between passenger and driver mutations in cancer.



Johannes Nübler

Univeristy of Tübingen, Ph.D.

Johannes works on the analysis of Hi-C and Micro-C data and modeling chromosomal organization in yeast, mouse, and human cells. His particular focus is on bridging large scale polymer models of chromatin with more fine-grained models of nucleosomes. He is interested in role of active processes in chromatin organization, e.g. transcription and chromatin remodeling.


Graduate Students

Anton Goloborodko

MIT Physics, Ph.D. Student

Anton's main interests are the structure of mitotic chromosomes and polymer simulations of chromosomal folding.



Nezar Abdennur

MIT Computational and Systems Biology, Ph.D. Student

My research interests lie at the intersection of nuclear organization and gene regulation.

nabdennur [at] gmail [dot] com


Martin Falk

MIT Physics, Ph.D. Student

My research interests are oriented towards a better understanding of nuclear structure and function via the construction and analysis of simple physical or mathematical models. Currently, my projects involve the use of polymer physics to study chromatin organization at the level of compartments.

mafafalk [at] gmail [dot] com


Hugo Brandão

Harvard Biophysics, Ph.D. Student

Hugo studies chromosome condensation and segregation in prokaryotes; he aims to elucidate fundamental principles of chromosome compaction by a combination of genomics, computational/theoretical modeling, and experiments.




E. M. Breville

MIT Physics (Ph.D./M.D./J.D. Harvard Biophysics/HST)

I joined MirnyLab in 2014, taking over daily caffination duties from Espresso. I continue my predecessor's research directions, including the long-term study of caffeination on H. sapiens. While I am currently the only wet-lab experimentalist in the group, I find the theorists easy to collaborate with and wonderfully open-minded.



Undergraduate students

Boryana Doyle

MIT Physics, class of 2017

boryana4 [at] mit [dot] edu